منابع مشابه
p53 and mdm2 in mantle cell lymphoma in leukemic phase.
BACKGROUND AND OBJECTIVES In mantle cell lymphoma (MCL), abnormalities additional to t(11;14) including those affecting genes involved in the p53 pathway, are important for disease development and progression. This study aimed to assess the frequency, relationship and impact of p53 abnormalities and those of its inhibitor mdm2 in blastoid and non-blastoid MCL in leukemic phase. DESIGN AND MET...
متن کاملHematopathology / LEUKEMIC NUCLEOLATED MANTLE CELL LYMPHOMA
Chronic lymphoproliferative disorders sometimes can be difficult to classify. We report 4 cases characterized by large cells with distinct central nucleoli, reminiscent of prolymphocytic leukemia, but shown on further workup to represent mantle cell lymphoma. At initial examination, the patients had generalized lymphadenopathy, splenomegaly, and a leukemic blood picture. The peripheral blood sh...
متن کاملMantle Cell Lymphoma with Multiple Lymphomatous Polyposis Presenting With Intussusceptions
Mantle cell lymphoma is an aggressive type of B-cell non-Hodgkin's lymphoma that originates from small to medium sized lymphocytes located in the mantle zone of the lymph node. The gastrointestinal tract is the predominant site of extranodal involvement in the form of multiple lymphomatous polyposis. Multiple lymphomatous polyposis due to mantle cell lymphoma presenting with intussusception is ...
متن کاملDiffuse large B-cell lymphoma in leukemic phase.
A 76-year-old man presented with right shoulder pain, weight loss, and night sweats. Complete blood count showed isolated thrombocytopenia (26 3 10/L). The blood film demonstrated medium to large atypical lymphoid cells (12% of leukocytes), many with polylobated nuclei or flower cell morphology (panel A, image obtained using Olympus BX51 microscope, 31000 magnification). Computerized tomography...
متن کاملDiffuse large B-cell lymphoma presenting in the leukemic phase
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma comprising a heterogeneous group of disorders with variable histological and clinical behavior. Although other lymphomas may present in the leukemic phase more frequently, this appearance is unusually observed among DLBCL cases. Diagnosing lymphoma is not always easy, and the patient's clinical status quite often may ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer
سال: 1999
ISSN: 0008-543X,1097-0142
DOI: 10.1002/(sici)1097-0142(19990901)86:5<850::aid-cncr22>3.0.co;2-z